Causes Of Type 2 Diabetes

Among the risk factors for type 2 diabetes are: 

Genetic Susceptibility
Type 2 diabetes develops when the body cannot produce sufficient insulin, or is unable to use insulin effectively. This increases the blood glucose level (hyperglycemia). Having certain gene or a combination of genes like the TCF7L2 gene can increase susceptibility to type 2 diabetes.
Obesity and Physical Inactivity
Increased risk for type 2 diabetes is associated with obesity and low physical activities. An imbalance between the intake of calories from food and drinks, and the calories burned by daily activities leads to weight gain, which in turn causes insulin resistance, and the onset of type 2 diabetes. Insulin resistance is when the body's muscle, fat and liver are not able to use insulin effectively.
Metabolic Syndrome
Metabolic syndromes is a group of health conditions common in people with insulin resistance. These include:
1. Higher than normal glucose levels
2. Increase in waist size due to excess abdominal fat
3. High blood pressure
4. Abnormal cholestirol and triglycides levels in the blood
People with metabolic syndrome have a high risk for type 2 diabetes and cardiovascular disease.
Others Causes Of Diabetes
The failure of insulin and glucagon to regulate normal blood glucose levels, problems in cell signaling arising from the interaction between insulin and its receptors, and dysfunction of the pancreas beta cells can increase the risk for type 2 diabetes.

Research Source: National Institute of Diabetes and Digestive and Kidney Diseases.

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